Viroporins, Examples of the Two-Stage Membrane Protein Folding Model
Identifieur interne : 000912 ( Main/Exploration ); précédent : 000911; suivant : 000913Viroporins, Examples of the Two-Stage Membrane Protein Folding Model
Auteurs : Luis Martinez-Gil ; Ismael MingarroSource :
- Viruses [ 1999-4915 ] ; 2015.
Abstract
Viroporins are small, α-helical, hydrophobic virus encoded proteins, engineered to form homo-oligomeric hydrophilic pores in the host membrane. Viroporins participate in multiple steps of the viral life cycle, from entry to budding. As any other membrane protein, viroporins have to find the way to bury their hydrophobic regions into the lipid bilayer. Once within the membrane, the hydrophobic helices of viroporins interact with each other to form higher ordered structures required to correctly perform their porating activities. This two-step process resembles the two-stage model proposed for membrane protein folding by Engelman and Poppot. In this review we use the membrane protein folding model as a leading thread to analyze the mechanism and forces behind the membrane insertion and folding of viroporins. We start by describing the transmembrane segment architecture of viroporins, including the number and sequence characteristics of their membrane-spanning domains. Next, we connect the differences found among viroporin families to their viral genome organization, and finalize focusing on the pathways used by viroporins in their way to the membrane and on the transmembrane helix-helix interactions required to achieve proper folding and assembly.
Url:
DOI: 10.3390/v7072781
PubMed: 26131957
PubMed Central: 4517110
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Viroporins, Examples of the Two-Stage Membrane Protein Folding Model</title><author><name sortKey="Martinez Gil, Luis" sort="Martinez Gil, Luis" uniqKey="Martinez Gil L" first="Luis" last="Martinez-Gil">Luis Martinez-Gil</name></author><author><name sortKey="Mingarro, Ismael" sort="Mingarro, Ismael" uniqKey="Mingarro I" first="Ismael" last="Mingarro">Ismael Mingarro</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26131957</idno><idno type="pmc">4517110</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517110</idno><idno type="RBID">PMC:4517110</idno><idno type="doi">10.3390/v7072781</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000033</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000033</idno><idno type="wicri:Area/Pmc/Curation">000033</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000033</idno><idno type="wicri:Area/Pmc/Checkpoint">000306</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000306</idno><idno type="wicri:Area/Ncbi/Merge">000470</idno><idno type="wicri:Area/Ncbi/Curation">000470</idno><idno type="wicri:Area/Ncbi/Checkpoint">000470</idno><idno type="wicri:Area/Main/Merge">000914</idno><idno type="wicri:Area/Main/Curation">000912</idno><idno type="wicri:Area/Main/Exploration">000912</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Viroporins, Examples of the Two-Stage Membrane Protein Folding Model</title><author><name sortKey="Martinez Gil, Luis" sort="Martinez Gil, Luis" uniqKey="Martinez Gil L" first="Luis" last="Martinez-Gil">Luis Martinez-Gil</name></author><author><name sortKey="Mingarro, Ismael" sort="Mingarro, Ismael" uniqKey="Mingarro I" first="Ismael" last="Mingarro">Ismael Mingarro</name></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Viroporins are small, α-helical, hydrophobic virus encoded proteins, engineered to form homo-oligomeric hydrophilic pores in the host membrane. Viroporins participate in multiple steps of the viral life cycle, from entry to budding. As any other membrane protein, viroporins have to find the way to bury their hydrophobic regions into the lipid bilayer. Once within the membrane, the hydrophobic helices of viroporins interact with each other to form higher ordered structures required to correctly perform their porating activities. This two-step process resembles the two-stage model proposed for membrane protein folding by Engelman and Poppot. In this review we use the membrane protein folding model as a leading thread to analyze the mechanism and forces behind the membrane insertion and folding of viroporins. We start by describing the transmembrane segment architecture of viroporins, including the number and sequence characteristics of their membrane-spanning domains. Next, we connect the differences found among viroporin families to their viral genome organization, and finalize focusing on the pathways used by viroporins in their way to the membrane and on the transmembrane helix-helix interactions required to achieve proper folding and assembly.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Carrasco, L" uniqKey="Carrasco L">L. Carrasco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carrasco, L" uniqKey="Carrasco L">L. Carrasco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Griffin, S D C" uniqKey="Griffin S">S.D.C. Griffin</name></author><author><name sortKey="Beales, L P" uniqKey="Beales L">L.P. Beales</name></author><author><name sortKey="Clarke, D S" uniqKey="Clarke D">D.S. Clarke</name></author><author><name sortKey="Worsfold, O" uniqKey="Worsfold O">O. 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Cross</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawano, K" uniqKey="Kawano K">K. Kawano</name></author><author><name sortKey="Yano, Y" uniqKey="Yano Y">Y. Yano</name></author><author><name sortKey="Matsuzaki, K" uniqKey="Matsuzaki K">K. Matsuzaki</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Martinez Gil, Luis" sort="Martinez Gil, Luis" uniqKey="Martinez Gil L" first="Luis" last="Martinez-Gil">Luis Martinez-Gil</name><name sortKey="Mingarro, Ismael" sort="Mingarro, Ismael" uniqKey="Mingarro I" first="Ismael" last="Mingarro">Ismael Mingarro</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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